What are the cardiac symptoms of sarcoidosis?

Updated: Sep 15, 2020
  • Author: Nader Kamangar, MD, FACP, FCCP, FCCM; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Heart block and sudden death may occur.

The incidence rate of ventricular tachyarrhythmias requiring implantable cardioverter-defibrillator therapy is estimated to be 15% per year in those patients with cardiac involvement. Prophylactic implantable cardioverter-defibrillator implantation should be considered in patients with cardiac sarcoidosis. [34] Corticosteroid therapy may be effective for ventricular arrhythmias in the early stage, but it is less effective in the late stage. [35]

In one study, 90.4% of ECGs in cardiac sarcoidosis patients contained at least fragmented QRS or a bundle-branch block (specificity 0.633), compared with 36.7% of noncardiac cardiac sarcoidosis patients (P< .01). If patients with sarcoidosis have these ECG findings, further workup is indicated. The Japanese Ministry of Health and Welfare has used a right bundle-branch block and advanced A-V block as 2 of the clinical diagnostic criteria used for diagnosis of cardiac sarcoidosis. [36]

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