What are the 7 signs of intraocular sarcoidosis?

Updated: Sep 15, 2020
  • Author: Nader Kamangar, MD, FACP, FCCP, FCCM; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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The consensus conference identified the following 7 signs in the diagnosis of intraocular sarcoidosis [33] :

  • Mutton-fat keratic precipitates (KPs)/small granulomatous KPs and/or iris nodules (Koeppe/Busacca)

  • Trabecular meshwork (TM) nodules and/or tent-shaped peripheral anterior synechiae (PAS)

  • Vitreous opacities displaying snowballs/strings of pearls

  • Multiple chorioretinal peripheral lesions (active and/or atrophic)

  • Nodular and/or segmental peri-phlebitis (+/- candlewax drippings) and/or retinal macroaneurysm in an inflamed eye

  • Optic disc nodule(s)/granuloma(s) and/or solitary choroidal nodule

  • Bilaterality

The laboratory investigations or investigational procedures judged to provide value in the diagnosis of ocular sarcoidosis in patients having the above intraocular signs included the following [33] :

  • Negative tuberculin skin test in a BCG-vaccinated patient or in a patient having had a positive tuberculin skin test previously

  • Elevated serum angiotensin-converting enzyme (ACE) levels and/or elevated serum lysozyme

  • Chest radiograph revealing BHL

  • Abnormal liver enzyme tests

  • Chest CT scan in patients with a negative chest radiograph result

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