What is the prognosis of sarcoidosis?

Updated: Sep 15, 2020
  • Author: Nader Kamangar, MD, FACP, FCCP, FCCM; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
  • Print
Answer

Many patients do not require therapy, and their conditions spontaneously improve. Markers for a poor prognosis include advanced chest radiography stage, extrapulmonary disease (predominantly cardiac and neurologic), and evidence of pulmonary hypertension. Multiple studies have demonstrated that the most important marker for prognosis is the initial chest radiography stage (see Table 2 below).

In one study of patients with radiographic stage IV sarcoidosis, during an average follow-up of 7 years, pulmonary hypertension was observed in 30% of cases. Long-term oxygen therapy was required in 12%. Survival was 84% at 10 yrs. Cause of death in 11% patients included refractory pulmonary hypertension, acute and chronic respiratory insufficiency, and heart sarcoidosis. Seventy-five percent of fatalities are directly attributable to respiratory causes. [28]

Table 1. Prognosis (Open Table in a new window)

Stage

Remission (%)

Asymptomatic at 5 y (%)

Chest Radiograph Clearing (%)

Mortality (%)

Stage I

60-90

95

54

0

Stage II

40-70

58

31

11

Stage III

10-20

25

10

18

Stage IV

0

N/A

0

N/A


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!