What is the incidence of sarcoidosis in the US?

Updated: Sep 15, 2020
  • Author: Nader Kamangar, MD, FACP, FCCP, FCCM; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

Incidence ranges from 5-40 cases per 100,000 population. The age-adjusted incidence for whites is 11 cases per 100,000 population. The incidence is considerably higher for African Americans, at 34 cases per 100,000 population. The prevalence is 10 times greater for African Americans than for whites. Approximately 20% of patients who are African American reported an affected family member, while only 5% of whites in the United States who have sarcoidosis state they have family members also diagnosed with sarcoidosis. African Americans seem to experience more severe and chronic disease. [25] In African Americans, siblings and parents of sarcoidosis cases have about a 2.5-fold increased risk for developing the disease.

Working on the World Trade Center (WTC) debris pile after the September 11, 2001 terrorist attacks was associated with sarcoidosis [26] (odds ratio, 9.1; 95% confidence interval, 1.1-74.0), but WTC dust cloud exposure was not (odds ratio, 1.0; 95% confidence interval, 0.4-2.8).


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