What is the role of plasmatic hypergammaglobulinemia in the pathophysiology of sarcoidosis?

Updated: Sep 15, 2020
  • Author: Nader Kamangar, MD, FACP, FCCP, FCCM; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

Active sarcoidosis has also been associated with plasmatic hypergammaglobulinemia. [20] B-cell accumulation has been shown in pulmonary lesions, and a beneficial effect with anti-CD20 monoclonal antibody therapy has been reported in select patients.


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