What noncorticosteroid agents are used in the treatment of sarcoidosis?

Updated: Sep 15, 2020
  • Author: Nader Kamangar, MD, FACP, FCCP, FCCM; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
  • Print

Noncorticosteroid agents include the following:

  • Methotrexate (MTX) has been a successful alternative to prednisone

  • Chloroquine and hydroxychloroquine have been used for cutaneous lesions, hypercalcemia, neurologic sarcoidosis, and bone lesions

  • Chloroquine has been found effective for acute and maintenance treatment of chronic pulmonary sarcoidosis [3, 4]

  • Cyclophosphamide has been rarely used with modest success as a steroid-sparing treatment in patients with refractory sarcoidosis [5, 6]

  • Azathioprine is best used as a steroid-sparing agent [7]

  • Chlorambucil may be beneficial in patients with progressive disease unresponsive to corticosteroids or when corticosteroids are contraindicated [8]

  • Cyclosporine may be of limited benefit in skin sarcoidosis or in progressive sarcoid resistant to conventional therapy [9]

  • Infliximab [10, 11] and thalidomide [12, 13] have been used for refractory sarcoidosis, particularly for cutaneous disease, as well as for the long-term management of extrapulmonary sarcoidosis [14]

  • Infliximab appears to be an effective treatment for patients with systemic manifestations such as lupus pernio, uveitis, hepatic sarcoidosis, and neurosarcoidosis

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!