What are the recommendations of the AASM for use of medications in the treatment of obstructive sleep apnea (OSA)?

Updated: Sep 15, 2020
  • Author: Himanshu Wickramasinghe, MD, MBBS; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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The American Academy of Sleep Medicine (AASM), in a practice parameter and review of medical therapies for OSA, [153, 218] listed the use of protriptyline as a guideline (patient care strategy based on level 2 or 3 evidence). [218] The use of modafinil was recommended for the treatment of residual sleepiness in persons with OSA and was considered a standard treatment (generally accepted patient care strategy with level 1 or excellent level 2 evidence).

The parameters state as standards that selective serotonin reuptake inhibitors, methylxanthines, and estrogen replacement therapy should not be considered for the treatment of OSA.

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