What is the effect of obstructive sleep apnea (OSA) on the production of nitric oxide?

Updated: Sep 15, 2020
  • Author: Himanshu Wickramasinghe, MD, MBBS; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

OSA has been associated with decreased production of nitric oxide. [119] Several studies have shown impaired vasodilator responses, as measured by either flow-mediated dilatation [120] or reactive hyperemic blood flow [121] techniques. Impaired flow-mediated dilatation was found to best correlate with the degree of oxygen desaturation in an epidemiologic cohort study. [122] Recent studies also indicate that cerebrovascular responses are impaired in patients with OSA.


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