What is the effect of obstructive sleep apnea (OSA) on CPR levels?

Updated: Sep 15, 2020
  • Author: Himanshu Wickramasinghe, MD, MBBS; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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OSA has been associated with increased production of reactive oxygen species [111] and other oxidative stress biomarkers. [112] It has also been associated with increased levels of several proinflammatory cytokines and markers associated with atherosclerosis. These include C-reactive protein (CRP) in both adults and adolescents, [113, 114] interleukin 6, [113] interleukin 18, [115] and matrix metalloproteinase 9. [116] However, at least one large epidemiologic study found no relationship between the severity of OSAHS and CRP levels. [117]

Oxidant-related microcirculatory endothelial dysfunction, in a group of patients who had no known vascular disease, improved when CPAP effectively treated the patient’s OSA, compared with no improvement in the control group. [118]

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