What is the prognosis of perimenopausal depression?

Updated: Jan 30, 2019
  • Author: Nita V Bhatt, MD, MPH; Chief Editor: Ana Hategan, MD, FRCPC  more...
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Although morbidity and mortality secondary to perimenopausal depression has not been studied, depression is known to be a significant health problem in women. According to the World Health Organization’s Global Burden of Disease Study, unipolar depression is the leading cause of disease-related disability in women. [36] In this study, unipolar major depression was second to only ischemic heart disease in terms of associated morbidity and mortality. [57]

The Study of Women’s Health Across the Nation suggests that women are at higher risk for major depression during and immediately after the menopausal transition and that the risk is smaller when they are premenopausal. [58]

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