What is the role of HRT in the treatment of mood disorders during menopause?

Updated: Jan 30, 2019
  • Author: Nita V Bhatt, MD, MPH; Chief Editor: Ana Hategan, MD, FRCPC  more...
  • Print


In women with mild mood-disorder symptoms that do not meet the criteria for depression, hormone replacement therapy may be considered. The effects of estrogen treatment have been studied in perimenopausal women without depression to see if it has a positive effect on mood or quality of life. Results from small studies have suggested a small positive impact on mood. [48, 49] However, most data suggest that, among healthy women without depression, estrogen has no favorable effect on quality of life or mood. [46, 50, 51]

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!