What is the role of mitomycin-C in renal transitional cell carcinoma treatment?

Updated: Nov 05, 2019
  • Author: Bagi RP Jana, MD, MBA, MHA, FACP; Chief Editor: E Jason Abel, MD  more...
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Answer

Rates of progression and recurrence of upper urinary tract UC after treatment with mitomycin-C are comparable to those after treatment with BCG. However, the possibility of complications is much less with mitomycin-C, making it more attractive as a first-line agent in the secondary prophylaxis of upper urinary tract UC. In 1 study, irrigation with mitomycin-C reduced the recurrence rate to 14.2%.


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