How is renal transitional cell carcinoma treated?

Updated: Nov 05, 2019
  • Author: Bagi RP Jana, MD, MBA, MHA, FACP; Chief Editor: E Jason Abel, MD  more...
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Once the diagnosis of upper urinary tract transitional cell carcinoma (TCC) has been made, treatment is mandatory. Surgical intervention is the main form of radical treatment for localized disease.

Local immunotherapy or chemotherapy can be attempted as an independent treatment method in cases of carcinoma in situ (CIS) or to reduce the recurrence rate after endoscopic management of upper urinary tract urothelial carcinoma (UC).

The role of radiation therapy in the management of upper urinary tract transitional cell carcinoma (TCC) is not well defined. Some studies suggest that radiation therapy may have some effect as adjuvant therapy to improve local control after radical surgical treatment for high-grade disease.

Medical therapy is usually indicated for patients with advanced disease or in whom surgical treatment is contraindicated (eg, because of poor general condition or the presence of advanced disease). Given the lack of data from randomized trials, routine use of neoadjuvant or adjuvant chemotherapy is not recommended.

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