What are the survival rates for renal transitional cell carcinoma?

Updated: Nov 05, 2019
  • Author: Bagi RP Jana, MD, MBA, MHA, FACP; Chief Editor: E Jason Abel, MD  more...
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Answer

The 5-year survival rate after radical surgery depends on the disease stage, as follows:

  • Stages Tis, Ta, or T1 – 91%

  • Stage T2 – 43%

  • Stages T3, T4, N1, or N2 – 23%

  • Stages N3 or M1 – 0%

TCC may develop in the contralateral kidney after radical nephroureterectomy. In a European multicenter dataset of patients who underwent nephroureterectomy for nonmetastatic TCC, a history of bladder TCC preceding the upper urinary tract TCC was the only predictor of TCC recurrence in the contralateral upper tract. [8] The 5-year probabilities of freedom from TCC in the contralateral upper tract TCC were as follows:

  • 96.6% for patients with de novo upper-tract disease

  • 91.1% for those having prior non–muscle-invasive bladder TCC

  • 55.3% for those with prior muscle-invasive bladder TCC

The 5-year survival rate in selected patients after conservative surgery is reported to be 70-90%.

Recurrences in the remaining urothelium after conservative treatment are relatively frequent because of the multifocal nature of TCCs. Ipsilateral recurrence rates may reach 25-50%. Most low-grade recurrences can be treated with repeat conservative excision. The 5-year survival rates in these patients with low-grade, low-stage disease can approach 100%.


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