What are the International Menopause Society guidelines on menopausal hormone replacement therapy (HRT)?

Updated: Sep 13, 2021
  • Author: Nicole K Banks, MD; Chief Editor: Richard Scott Lucidi, MD, FACOG  more...
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The International Menopause Society issued guidelines on menopausal hormone therapy that include the following recommendations [26, 27]

  • Hormone therapy continues to be the most effective treatment for menopause symptoms such as vasomotor symptoms and urogenital atrophy, according to the International Menopause Society.

  • Menopausal hormone therapy, including tibolone and the combination of conjugated equine estrogens and bazedoxifene (CE/BZA), is the most effective treatment for vasomotor symptoms associated with menopause.

  • If menopausal hormone therapy is contraindicated or not desired, selective serotonin reuptake inhibitors or serotonin-norepinephrine reuptake inhibitors such as paroxetine, escitalopram, venlafaxine, and desvenlafaxine may be considered, as well as gabapentin.

  • Menopausal hormone therapy can be initiated in postmenopausal women at risk of fracture or osteoporosis before 60 yr of age or within 10 yr after menopause.

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