How does menopausal hormone replacement therapy (HRT) affect gallbladder disease risk?

Updated: Sep 13, 2021
  • Author: Nicole K Banks, MD; Chief Editor: Richard Scott Lucidi, MD, FACOG  more...
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Cholelithiasis is common among postmenopausal women, as increasing age and obesity are considered risk factors for the condition. In various studies including the WHI, this risk further increased in postmenopausal women receiving HT. The annual incidence for any gallbladder event was 78 events per 10,000 person-years for women taking estrogen-only preparations versus 47 events per 10,000 person-years for placebo. [3] By comparison, rates were 55 per 10,000 person-years for combined estrogen and progestogen versus 35 events per 10,000 person-years for placebo.

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