How does menopausal hormone replacement therapy (HRT) affect thromboembolism risk?

Updated: Sep 24, 2019
  • Author: Nicole K Banks, MD; Chief Editor: Richard Scott Lucidi, MD, FACOG  more...
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Answer

Answer

Various studies have shown concordance in the observation of an increased risk of thromboembolism with HT. The WHI study demonstrated combined HT increased the risk of venous thrombosis and pulmonary embolism in 15 per 10,000 women per year. The risk of venous thrombosis increased for women given an estrogen-only regimen, but their risk of developing pulmonary emboli was not statistically significant.

An underlying coagulopathy increases the occurrence of thromboembolic complications. Transdermal HT may be associated with a lowered risk.


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