What are the contraindications for menopausal hormone replacement therapy (HRT)?

Updated: Sep 13, 2021
  • Author: Nicole K Banks, MD; Chief Editor: Richard Scott Lucidi, MD, FACOG  more...
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No absolute contraindications of HT have been established. However, relative contraindications exist in certain clinical situations, such as patients with the following findings:

  • A history of breast cancer*

  • A history of endometrial cancer*

  • Porphyria

  • Severe active liver disease

  • Hypertriglyceridemia

  • Thromboembolic disorders

  • Undiagnosed vaginal bleeding

  • Endometriosis

  • Fibroids

* Note that many clinicians do not prescribe HT for women with a previous history of breast or endometrial cancer.

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