What is the role of SNRIs in the treatment of postpartum depression?

Updated: Oct 11, 2019
  • Author: Saju Joy, MD, MS; Chief Editor: Christine Isaacs, MD  more...
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Serotonin/norepinephrine reuptake inhibitors (SNRIs) such as venlafaxine (Effexor) 75-300mg/day or duloxetine (Cymbalta) 40-60mg/day are also highly effective for managing depression and anxiety.

Adverse effects of SNRIs include those of the SSRIs as well as sleep disturbances, constipation, and abnormal vision.

Although SSRIs have been well studied in the treatment of depression, only recently have randomized controlled trials in the postpartum population become available. These randomized controlled trials demonstrate patients undergoing pharmacologic treatment alone have a higher response and remission with an SSRI compared with placebo. [60] However, patients undergoing psychotherapy did not demonstrate a significant additive benefit when an SSRI was added to their therapy, as compared with placebo. [61]

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