What are the adverse risks of HRT in the treatment of menopausal symptoms?

Updated: Jun 06, 2018
  • Author: PonJola Coney, MD; Chief Editor: Richard Scott Lucidi, MD, FACOG  more...
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Disease risk

In the Women’s Health Initiative (WHI), greater safety and possible benefit from hormone or estrogen therapy for women in their 50s, with potential harm for older women, were observed with respect to the following [6] :

  • Coronary artery disease (CAD)

  • Total myocardial infarction

  • Colorectal cancer

  • Total mortality

  • Global index of chronic diseases

Although immediate use of hormone or estrogen therapy in the early postmenopausal time may reduce the risk of CAD, the WHI clearly showed that women more than 9 years post menopause should not be started on hormone therapy or estrogen therapy for CAD prevention.

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