Which endometrial changes are characteristic of menopause?

Updated: Jun 06, 2018
  • Author: PonJola Coney, MD; Chief Editor: Richard Scott Lucidi, MD, FACOG  more...
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Endometrial changes

  • Endometrial biopsy can show a range of endometrial appearances, from mildly proliferate to atrophic

  • No secretory changes are observed after menopause, because no ovulation occurs and therefore no corpus luteum forms to produce progesterone

  • Endometrial hyperplasia is a sign of hyperstimulation by estrogen from either endogenous sources or replacement therapy and may be a precursor of endometrial cancer

  • Endometrial hyperplasia can also be suggested by ultrasonographic findings (ie, endometrial thickness >5 mm), which are useful for excluding hyperplasia and cancer of the endometrium in postmenopausal women

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