Which treatments for chronic hypertension during pregnancy reduce the risk of developing superimposed preeclampsia?

Updated: Jun 12, 2018
  • Author: Michael P Carson, MD; Chief Editor: Edward H Springel, MD, FACOG  more...
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Pharmacologic treatment and normalization of chronic hypertension does not reduce the risk of developing superimposed preeclampsia. Other therapies that have been tried include low-dose acetylsalicylic acid (ASA), [27] supplemental calcium, [28] salt restriction, [29] supplemental magnesium, [30] and fish oil therapy. [31] Although well-designed randomized trials of ASA in high-risk populations showed no benefit in reducing the frequency of preeclampsia, a meta-analysis reported an approximate 15% reduction in preeclampsia among pregnant women taking low-dose ASA when women began taking it before 16 weeks' gestation. [32, 33] This therapy appears very safe and might be considered in high-risk women. None of the other therapies have demonstrated any significant preventive benefit.

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