What is the screening algorithm for preeclampsia/gestational hypertension in the UK?

Updated: Jun 12, 2018
  • Author: Michael P Carson, MD; Chief Editor: Edward H Springel, MD, FACOG  more...
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Researchers in the United Kingdom have developed a method for first-trimester screening to identify women at risk for the development of preeclampsia or gestational hypertension. The screening algorithm uses a combination of maternal variables, including mean arterial pressure, uterine artery pulsatility index, pregnancy-associated plasma protein-A, and placental growth factor. The algorithm proved especially effective for predicting early preeclampsia (ie, requiring delivery before 34 weeks). [16]  Screening strategies for preeclampsia other than evaluating for risk factors through a detailed medical history are not currently recommended by ACOG or SMFM. [17]

A cohort study that covered over 13,000 pregnancies by Egeland et al found that gestational hypertension and preeclampsia share several preconception risk factors, some of which could be modified to reduce the risk of adverse pregnancy outcomes. The baseline risk factors shared among gestational hypertension and preeclampsia were: family history of diabetes mellitus, a women's own diabetes status prior to conception, a high total cholesterol/high-density lipoprotein cholesterol ratio (>5), overweight and obesity, and elevated blood pressure status. For preeclampsia but not gestational hypertension, a family history of myocardial infarction before 60 years of age and elevated triglyceride levels also predicted risk. [18, 19]

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