Which medications in the drug class Antiemetics are used in the treatment of Ovarian Cancer?

Updated: Aug 10, 2020
  • Author: Andrew E Green, MD; Chief Editor: Yukio Sonoda, MD  more...
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Answer

Antiemetics

Antiemetics are used for the prevention and treatment of nausea and vomiting associated with chemotherapy.

Ondansetron (Zofran)

Ondansetron is a selective 5-HT3 receptor antagonist that blocks serotonin both peripherally and centrally. It prevents nausea and vomiting associated with emetogenic cancer chemotherapy (eg, high-dose cisplatin) and complete body radiotherapy.

Granisetron (Kytril)

Granisetron is also a 5-HT3-receptor antagonist. It is indicated for the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy, including high-dose cisplatin.

Palonosetron (Aloxi)

Palonosetron is a selective 5-HT3 receptor antagonist with long half-life (40 h). It is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting. Palonosetron blocks 5-HT-3 receptors peripherally and centrally in the chemoreceptor trigger zone.

Dexamethasone (Decadron)

Dexamethasone is used as an antiemetic in low doses during chemotherapy. It is usually employed in multiagent antiemetic regimens with 5HT-3 receptor antagonists.


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