What are the NCCN guidelines on ovarian cancer prevention?

Updated: Aug 10, 2020
  • Author: Andrew E Green, MD; Chief Editor: Yukio Sonoda, MD  more...
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Answer

The NCCN recommends bilateral salpingo-oophorectomy (RRSO) for risk reduction in women with BRCA1 or BRCA2 mutations, ideally at the age of 35-40 years and upon completion of childbearing or at an individualized age based on earliest age of ovarian cancer diagnosed in the family. [125] Both the USPSTF and ACOG also support offering salpingo-oophorectomy for risk reduction to women with BRCA1 or BRCA2 mutations. [124, 128] ESMO guidelines concur and suggest that the surgery take place after age 35 and childbearing is completed. [127]

The NCCN guidelines also note that women considering RRSO should be made aware of the increased risk of osteoporosis and cardiovascular disease associated with premature menopause, as well as the potential effects of possible cognitive changes, accelerated bone loss, and vasomotor symptoms on quality of life. [125]


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