How is stage III ovarian cancer defined?

Updated: Aug 10, 2020
  • Author: Andrew E Green, MD; Chief Editor: Yukio Sonoda, MD  more...
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Answer

In stage III, tumor involves one or both ovaries, with cytologically or histologically confirmed spread to the peritoneum outside the pelvis, and/or metastasis to the retroperitoneal lymph nodes. Substages are as follows:

  • Stage IIIA - Positive retroperitoneal lymph nodes and/or microscopic metastasis beyond the pelvis

  • Stage IIIA1 -  Positive retroperitoneal lymph nodes only (IIIA1), metastasis ≤10 mm (IIIA1[ii]), or metastasis >10 mm (IIIA1[ii])

  • Stage IIIA2 - Microscopic, extrapelvic (above the brim) peritoneal involvement ± positive retroperitoneal lymph nodes

  • Stage IIIB - Macroscopic, extrapelvic, peritoneal metastasis ≤2 cm ± positive retroperitoneal lymph nodes; includes extension to capsule of liver/spleen

  • Stage IIIC - Macroscopic, extrapelvic, peritoneal metastasis >2 cm ± positive retroperitoneal lymph nodes; includes extension to capsule of liver/spleen


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