Which chemotherapy agents are used in the treatment of ovarian cancer?

Updated: Aug 10, 2020
  • Author: Andrew E Green, MD; Chief Editor: Yukio Sonoda, MD  more...
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Answer

Chemotherapy

Postoperative chemotherapy is indicated in all patients with ovarian cancer, except those who have surgical-pathologic stage I disease with low-risk characteristics. Standard postoperative chemotherapy for ovarian cancer is combination therapy with a platinum compound and a taxane (eg, carboplatin and paclitaxel). Additional agents for recurrent disease include the following:

  • Liposomal doxorubicin
  • Etoposide
  • Topotecan
  • Gemcitabine
  • Vinorelbine
  • Ifosfamide
  • Fluorouracil
  • Melphalan
  • Altretamine
  • Bevacizumab
  • Olaparib
  • Niraparib
  • Rucaparib
  • Pazopanib

Adjunctive medications include the following:

  • Cytoprotective agents (eg, mesna)
  • Antiemetics (eg, ondansetron, granisetron, palonosetron, dexamethasone)

See Treatment and Medication for more detail.


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