What are the NCCN and ASCO treatment guidelines for radiation-induced nausea and vomiting (RINV)?

Updated: May 31, 2018
  • Author: Winston W Tan, MD, FACP; more...
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For patients receiving radiation therapy (RT) to the upper abdomen/localized sites or total body irradiation, the NCCN recommends pretreatment for each day of RT with either of the following:

  • Granisetron with or without dexamethasone
  • Ondansetron with or without dexamethasone

For breakthrough emesis, the NCCN recommendations are the same as for CINV breakthrough treatment. For management of emesis during concurrent radiation and chemotherapy, the NCCN and ASCO guidelines agree that the optimal approach is to give antiemetic prophylaxis according to the emetogenicity of the chemotherapy. [1, 3]

in the setting of combined modality treatment with chemo-radiation it is important to tailor the management individually and depending on the emetogenic potential of the drug.

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