Which treatments for chemotherapy-induced nausea and vomiting (CINV) do not have established efficacy?

Updated: May 31, 2018
  • Author: Winston W Tan, MD, FACP; more...
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The effectiveness of the following treatments was not considered established:

  • Acupressure
  • Acupuncture/electroacupuncture
  • Acustimulation
  • Aromatherapy
  • Lorazepam [Ativan], diphenhydramine [Benadryl], and haloperidol [Haldol] gel (ABH gel)
  • Ayurvedic drugs
  • Carbamazepine
  • Chamomilla recutita
  • Electronic antinausea device (ELANI)
  • Exercise
  • Ginger
  • Grape Juice
  • Guided imagery/imagery alone
  • Haloperidol
  • Herbal medicine
  • Hologram bracelet
  • Institutional initiatives
  • Massage/aromatherapy massage
  • Metoclopramide (prophylactic)
  • Metopimazine
  • Mirtazapine
  • Nevasic audio
  • Ondansetron as rescue medication
  • Prochlorperazine for breakthrough CINV
  • Progressive muscle relaxation (PMR)
  • Psychoeducation/psychoeducational interventions
  • Thalidomide
  • Therapeutic touch
  • Yoga

The ONS also found cocculine unlikely to be effective and that expert opinion supports the adjunctive use of lorazepam for CINV prevention.

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