What are the NCCN guidelines on the diagnosis of medullary thyroid carcinoma (MTC)?

Updated: Jun 24, 2020
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The NCCN recommends the following diagnostic procedures when FNAB results indicate MTC [5] :

  • Basal serum calcitonin level
  • CEA level
  • Pheochromocytoma screening
  • Serum calcium assay
  • Consider genetic counseling
  • Screen for  RET proto-oncogene mutations (exons 10, 11, 13-16)
  • Thyroid and neck ultrasound (including central and lateral compartments), if not previously done
  • Consider evaluation of vocal cord mobility
  • Consider contrast-enhanced CT of chest and mediastinum, MRI or 3-phase CT of liver if N1 disease or calcitonin >400 pg/mL

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