What are alternative imaging studies for patients with risk factors for contrast-induced nephropathy (CIN)?

Updated: Feb 21, 2020
  • Author: Anita Basu, MD, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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In patients with risk factors for CIN, the possibility of alternative imaging studies that do not need contrast should be explored. MRI with gadolinium is no longer considered a safe alternative to iodinated contrast because of the risk of nephrogenic systemic fibrosis (NSF), an irreversible, debilitating condition seen mostly in patients with an eGFR of less than 30 mL/min/1.73 m2. Of gadolinium-based contrast agents, gadoteridol and gadobenate dimeglumine are considered to pose the lowest risk of NSF; no association of either agent with an unconfounded case of NSF has yet to be established. [60]

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