Which strategies are effective in the prevention of contrast-induced nephropathy (CIN)?

Updated: Feb 21, 2020
  • Author: Anita Basu, MD, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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A systematic review and meta-analysis of prevention strategies for CIN found that, compared with intravenous (IV) saline only, the following had clinically important and statistically significant benefits when used in combination with IV saline [33] :

  • Low-dose NAC: Risk ratio (RR), 0.75
  • NAC, in patients receiving low-osmolar contrast media (LOCM): RR, 0.69
  • Statins plus NAC (versus NAC plus IV saline): RR, 0.52

A clinically important difference that was not statistically significant was found with the following, when compared with IV saline only [33] :

  • Sodium bicarbonate, in patients receiving LOCM
  • Statins plus IV saline
  • Ascorbic acid

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