What is the mortality rate of hyponatremia?

Updated: Aug 16, 2019
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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The mortality of patients with hyponatremia (Na+ < 130 mEq/L) is increased 60-fold compared with that of patients without documented hyponatremia, although this may be partly related to their comorbid conditions rather than to the hyponatremia itself. Predictors for higher morbidity and mortality rates include being hospitalized, acute onset, and severity of hyponatremia. [13] When the Na+ concentration drops below 105 mEq/L, life-threatening complications are much more likely to occur. [17]

In a retrospective case note review by Clayton and colleagues, patients with a multifactorial cause for hyponatremia in an inpatient setting had significantly higher mortality rates. [20] The etiology of hyponatremia was a more important prognostic indicator than the level of absolute serum Na+ in the patients. The outcome was least favorable in patients with normal sodium levels on admission who became hyponatremic during the course of their hospitalization.

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