How is urea administered in chronic syndrome of inappropriate antidiuretic hormone secretion (SIADH)?

Updated: Aug 16, 2019
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Urea can be administered on a long-term basis (0.5 g/kg body weight) without major adverse effects. Urea is available as a powder, which is dissolved in water and taken orally during or after meals. To avoid gastric upset, it can be taken with an antacid. Urea can also be used continuously in patients with cerebral hemorrhage via a gastric tube or intravenously to prevent a rapid fall in intracranial pressure.

Urea should be used with great care in patients with serum creatinine of 2 mg/dL or more, BUN 80 mg/dL or more, or bilirubin of 2 mg/dL or more, to avoid progressive azotemia, hyperammonemia, and hepatic encephalopathy. Hypernatremia and dehydration may occur if the patient does not have free access to water.

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