What are differential diagnoses of syndrome of inappropriate antidiuretic hormone secretion (SIADH) in which renal water handling is impaired?

Updated: Aug 16, 2019
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Conditions in which renal water handling is impaired include the following:

  • Effective circulating volume depletion - GI losses (eg, diarrhea, vomiting), renal losses (eg, diuretic therapy, adrenal insufficiency, primary renal salt wasting), skin losses, edematous disorders (congestive heart failure, cirrhosis with portal hypertension, severe nephrotic syndrome)

  • Renal failure - Acute kidney injury (AKI) or chronic kidney disease (CKD)

  • Other states of ADH excess - Cortisol deficiency, hypothyroidism, exogenous ADH (eg, deamino-D-arginine-vasopressin, vasopressin, oxytocin)

  • Decreased solute intake

  • Nephrogenic syndrome of inappropriate anti-diuresis (NSIAD)

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