What is the prevalence of syndrome of inappropriate antidiuretic hormone secretion (SIADH) in the US?

Updated: Aug 16, 2019
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Hyponatremia is the most common electrolyte derangement occurring in hospitalized patients. When defined as plasma Na+ concentration of less than 135 mEq/L, the prevalence of hyponatremia in hospitalized patients has been reported in different studies as being between 2.5% and 30%. [11, 12, 13, 14] In the majority of cases, the hyponatremia was hospital acquired or aggravated by the hospitalization and may be secondary to the administration of hypotonic intravenous (IV) fluids. [11] SIADH can also arise postoperatively from stress, pain, and medications used. However, not all hospital-acquired hyponatremia is SIADH and SIADH should be differentiated from the hyponatremia that occurs in patients with limited capacity to excrete free water, such as in patients with chronic kidney disease.

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