Which drugs may induce syndrome of inappropriate antidiuretic hormone secretion (SIADH) by potentiating the effects of arginine vasopressin (AVP) action?

Updated: Aug 16, 2019
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Drugs that potentiate the effects of AVP action (primarily facilitate peripheral action of ADH) are as follows:

  • Clofibrate

  • Griseofulvin

  • Hypoglycemic agents – Metformin, phenformin, tolbutamide

  • Oxytocin (large doses)

  • Prostaglandin synthetase inhibitors (inhibit renal PGE2 synthesis) – Indomethacin, aspirin, nonsteroidal anti-inflammatory drugs

  • Theophylline

  • Triiodothyronine

  • Vasopressin analogs (eg, AVP, DDAVP)

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