What are the treatment options for syndrome of inappropriate antidiuretic hormone secretion (SIADH) in an acute setting?

Updated: Aug 16, 2019
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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In an acute setting (< 48 hours since onset) where moderate symptoms are noted, treatment options for hyponatremia include the following:

  • 3% hypertonic saline (513 mEq/L)

  • Loop diuretics with saline

  • Vasopressin-2 receptor antagonists (aquaretics, such as conivaptan or tolvaptan)

  • Water restriction

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