What is the role of corticosteroids in the treatment of HIV-associated nephropathy (HIVAN)?

Updated: May 09, 2018
  • Author: Moro O Salifu, MD, MPH, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Answer

A number of case reports have suggested that corticosteroids offer some short-term benefit in HIVAN. [20] In one report, results from a pretreatment and posttreatment kidney biopsy suggested that an improvement in renal function was associated with a reduced number of lymphocytes and macrophages infiltrating the interstitium.

In another report, of 20 patients who were treated with prednisone, 60 mg/day for 2-11 weeks, followed by a slow taper, [21] 8 patients required maintenance dialysis, 11 died from complications, and 7 were alive and no longer had ESRD after a follow-up of 44 weeks.


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