How is HIV-associated nephropathy (HIVAN) treated?

Updated: May 09, 2018
  • Author: Moro O Salifu, MD, MPH, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Answer

Although there are no guiding clinical studies, some experts recommend consideration of therapy in all patients with HIV-associated nephropathy (HIVAN). Initiation or adjustment of antiretroviral therapy may be indicated. See Antiretroviral Therapy for HIV Infection for specific information, including recommendations for dosage adjustments for renal insufficiency.

Angiotensin-converting enzyme (ACE) inhibitors and corticosteroids have been studied for use in HIVAN. Some reports on pediatric populations suggest that cyclosporine can be effective in reducing proteinuria in persons with HIVAN. The usefulness of cyclosporine therapy for HIVAN warrants further study. Researchers are pursuing several promising therapeutic strategies. Patients who progress to end-stage renal disease (ESRD) require dialysis and consideration of renal transplantation in carefully selected cases.


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