What is the role of fluoroquinolones in the treatment of acute pyelonephritis?

Updated: Jul 01, 2021
  • Author: Tibor Fulop, MD, PhD, FACP, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

The fluoroquinolones are well tolerated and quite effective. They are probably the outpatient antibiotic treatment of choice for pyelonephritis. They (along with TMP-SMX) do not eradicate the protective lactobacilli from the vagina. An important caveat for the use of fluoroquinolones in the elderly is their potential to cause aortic aneurysm or dissection; hypoglycemia; and a variety of neuropsychiatric symptoms, ranging from seizures to worsening of dementia. [36]


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