What is the IDSA recommendation for duration of antibiotic therapy for acute pyelonephritis?

Updated: Jul 01, 2021
  • Author: Tibor Fulop, MD, PhD, FACP, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Acute pyelonephritis has customarily been treated with 14 days of antibiotics, and the IDSA guidelines maintain this recommendation for TMP-SMX and beta-lactam agents. However, evidence suggests that in young, healthy women who are receiving a fluoroquinolone, including ciprofloxacin, the course of treatment can be shortened to 7 days. Levofloxacin, 750 mg/day, can be given for 5 days. [34, 35] Young, healthy males should complete a 14-day course. [3]


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