What is the efficacy of antibiotic therapy for acute pyelonephritis treatment?

Updated: Jul 01, 2021
  • Author: Tibor Fulop, MD, PhD, FACP, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Patients presenting with acute pyelonephritis can be treated with a single dose of a parenteral antibiotic followed by oral therapy, provided they are monitored within the first 48 hours. In a study of febrile, nonpregnant women presenting with symptoms of acute pyelonephritis, 25% were hospitalized; of nonhospitalized patients, 80% were treated with a single parenteral dose of ceftriaxone or gentamicin, followed by oral therapy (usually TMP-SMX). Twelve percent returned with persistent symptoms, most in the first day; most of those patients were admitted. [5]


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