What is the pathogenesis of corticomedullary abscess in patients with acute pyelonephritis represent?

Updated: Jul 01, 2021
  • Author: Tibor Fulop, MD, PhD, FACP, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

The pathology represents a spectrum of disease, as follows:

  • Acute focal bacterial nephritis (eg, acute lobar nephroma, focal pyelonephritis) that affects a single renal lobe, with interstitial inflammation represented by marked polymorphonuclear leukocytes
  • Acute multifocal bacterial nephritis, with a similar process throughout the kidney that produces liquefaction and abscess formation
  • Xanthogranulomatous pyelonephritis, with chronic parenchymal infection, granulomatous tissue, and perirenal fibrosis
  • Emphysematous pyelonephritis, with severe, necrotizing infection

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