What is the role of siderophores and protectins in the pathogenesis of acute pyelonephritis (kidney infection)?

Updated: Jul 01, 2021
  • Author: Tibor Fulop, MD, PhD, FACP, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Siderophores are involved in iron uptake, an essential element for bacteria, and possibly adhesion. Protectins and their contributions to virulence include the following:

  • Lipopolysaccharide (LPS) coatings: resist phagocytosis
  • Tra T and Iss: resist action of complement
  • Omp T: cleave host defense proteins (eg, immunoglobulins)

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