What are the indications for use of tolvaptan in the treatment of autosomal dominant polycystic kidney disease (ADPKD)?

Updated: Mar 24, 2020
  • Author: Roser Torra, MD, PhD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Tolvaptan (Jynarque), a selective vasopressin V2-receptor antagonist, was approved in the U.S. in April 2018 to slow kidney function decline in adults at risk of rapidly progressing ADPKD. Approval was based on several phase 3 clinical trials. [38, 37, 39]


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