What is the role of urinary proteomic biomarkers in the workup of autosomal dominant polycystic kidney disease (ADPKD)?

Updated: Mar 24, 2020
  • Author: Roser Torra, MD, PhD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Urinary proteomic biomarkers may have the potential for diagnosis and prognosis of ADPKD. In a large clinical proteomic study, investigators reported that the performance of urinary peptidomic biomarker scores in ADPKD is superior to that of other biochemical markers in young patients with this disease and that proteomic profiling is potentially useful in the diagnosis and risk stratification of ADPKD. [30] In the study, urine samples from 1,048 patients were analyzed to characterize the urinary peptidomic pattern of patients with early stage ADPKD. [30]


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