What are the signs and symptoms of nephrolithiasis in autosomal dominant polycystic kidney disease (ADPKD)?

Updated: Mar 24, 2020
  • Author: Roser Torra, MD, PhD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Nephrolithiasis occurs in 20-30% of patients with ADPKD. Consider this condition in patients with acute pain and hematuria. In contrast to kidney stones in the general population, which most often consist of calcium oxalate, uric acid stones form in as many as 50% of patients with ADPKD. Metabolic abnormalities (eg, decreased urinary citrate) contribute to uric acid stone formation.


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