What causes portal hypertension in autosomal dominant polycystic kidney disease (ADPKD)?

Updated: Mar 24, 2020
  • Author: Roser Torra, MD, PhD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Bilateral nephrectomy in patients with massively enlarged livers may cause portal hypertension. This typically manifests as severe ascites or esophageal varices. The enlarged liver may also cause malnutrition, and in such cases, patients may need a partial resection of the liver or hepatic transplantation.

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