Which patient groups are at highest risk for polycystic liver disease in autosomal dominant polycystic kidney disease (ADPKD)?

Updated: Mar 24, 2020
  • Author: Roser Torra, MD, PhD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Women are more likely to have more and larger hepatic cysts than men; this correlates with estrogen exposure and increases with gravidity in women. Liver size in massive polycystic liver disease tends to stabilize after menopause. Hepatic cysts occur in almost 50% of affected patients. Cysts occur in approximately 20% of patients during the third decade of life and in 75% during the seventh decade of life. They are rare in children, and the frequency increases with age. Pancreatic cysts occur at a rate of 9% in patients older than 20 years.


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